Born and raised in Athens, Greece, Chrysi Sylaidi’s early education included the Greek Public School of her neighborhood and later onViky Manda Papadatou- a cooperative partner school of the Deutsche Schule Athen. For middle and high school, she went to the historic Ziridis School in Athens. 

Throughout her school years, Sylaidi organically gravitated toward creative expression and performance. Whenever opportunities to perform in any capacity arose, she found herself involved, enjoying the experience, and discovering an affinity for it. At the young age of 13, she and her friends spontaneously joined the Ziridis Classical Theatre Group where an unexpectedly profound relationship with theatre and the collaborative process of making it started being developed. Her experience performing as Hecuba in Euripides' tragedy, a performance which received second place at the National Greek Theatre Competition Awards, became a defining moment. Upon graduating high school she was honored with the Ziridis Award for Drama.

Sylaidi attended the Athens University of Economics and Business, where she received an honorary award for being admitted as the third-ranked candidate nationally and was granted a full scholarship. While pursuing her degree, she continued acting in college productions staged at several of Athens's most distinguished theatres, as well as in regional festivals.

She earned a degree in Economics with a major in Economic Theory and Politics before moving to New York City to pursue her professional training at the Stella Adler Studio of Acting, completing its three-year Professional Conservatory program in 2019. Her additional training includes intensive study of Ancient Greek Drama at the National Theatre of Greece and two years of work in Jerzy Grotowski’s practices alongside Erica Fae.

Since relocating to New York, Sylaidi has worked extensively across the city's theatre community in classical and contemporary productions. Her recent credits include Lorraine in Liberty Scrap at Culture Lab LIC, directed by T. Ryder Smith included in The New York Times’ Off- Broadway recommendations; Athena/Helen in Euripides' The Trojan Women at the Off- Broadway production of the LaGuardia Performing Arts Center in collaboration with Eclipses Group Theatre NY; Nora in Magma at Lincoln Center; The Narrator in Time Zone Free at Rattlestick Playwrights Theatre; Chorus Lead in In Chorus, a production by Eclipses Group Theatre NY in collaboration with the National Theatre of Greece; and Max in Science Project at The Flea Theatre, a Fled Collective production that went on to win 7 consecutive rounds of the known late night competition, Serials.

Her other New York credits include Cassius in Julius Caesar, Marya Antonova/Bobchinsky in The Government Inspector, Hermione in The Winter's Tale, Pope Joan/Louise in Top Girls, Costard in Love's Labour's Lost, Dogberry in Much Ado About Nothing, and Rhonda in Almost, Maine. She has also performed with Theatre East at Powerhouse Theatre, Rattlestick Playwrights Theatre, The Flea, LaGuardia Performing Arts Center, Culture Lab LIC, the Greek Cultural Center, and other New York venues.

Sylaidi received second place at the BroadwayWorld Awards 2020 for Performer of the Decade for her leading performance in Golden Girl by the Sea, presented at the Greek Cultural Center in New York. Other notable performances include the critically acclaimed I Want a Country by Andreas Flourakis produced by EGTNY and TeamTheatre, and the The Spitting Image of the Departed (Ftistos o Makaritis), produced by the Greek Cultural Center. Her screen credits include Macrame in the award-winning comedy series Stephie With A Why and Through My Eyess a short documentary directed by Inés Braun. 

As a producer, Sylaidi has worked on productions including I Want a Country by Andreas Flourakis, a collaboration between TeamTheatre and Eclipses Group Theatre NY sponsored by the New York State Council on the Arts; the Off-Broadway production of The Night Alive at the Chain Theatre; the Global Forms Theatre Festival at Rattlestick Playwrights Theatre; and TeamTheatre's critically acclaimed Almost Maine and Fun Fast Feb Festival. 

As a director, she directed No Friends by Myrna Davonne, and directed and produced TeamTheatre's short film BAD JUJU currently in post production.

Sylaidi is the co-Founder and co-Artistic Director of TeamTheatre, an award-winning, multicultural theatre company dedicated to celebrating diversity through theatre. She is also a resident artist at the Hellenic Cultural Center in New York, a member of Dirty Laundry Theatre, and a member of the Stella Adler Center of the Arts, Alumni Council (SASAC).

Her work continues to connect her Greek and European theatrical roots with her evolving career in New York and the US.